{"id":107512,"date":"2020-02-24T09:01:09","date_gmt":"2020-02-24T08:01:09","guid":{"rendered":"https:\/\/sdk.mk\/?p=107512"},"modified":"2020-02-24T09:01:09","modified_gmt":"2020-02-24T08:01:09","slug":"ju-njoftojme-me-semundjet-e-rralla-fibrodisplazija-osifikuese-progressive","status":"publish","type":"post","link":"https:\/\/sdk.mk\/index.php\/uncategorized-sq\/ju-njoftojme-me-semundjet-e-rralla-fibrodisplazija-osifikuese-progressive\/","title":{"rendered":"JU NJOFTOJM\u00cb ME S\u00cbMUNDJET E RRALLA: FIBRODISPLAZIJA OSIFIKUESE PROGRESSIVE"},"content":{"rendered":"<div class=\"f52428582a4b906b2d2e2a7d733c7d27\" data-index=\"7\" style=\"float: none; margin:10px 0 10px 0; text-align:center;\">\n<!-- MSP Ads Asynchronous JS Tag - Generated with Revive Adserver v5.4.1 -->\r\n<ins data-revive-zoneid=\"167\" data-revive-id=\"060fdb01f6430ec164d3519234aa4967\"><\/ins>\r\n<script async src=\"\/\/panel.ads.com.mk\/www\/delivery\/asyncjs.php\"><\/script>\n<\/div>\n<p><a href=\"https:\/\/www.youtube.com\/watch?v=hrZGke1RFFE&amp;list=PLPGcigDEy-qj0I1um2ByEqy4a1IdVRjzf&amp;index=25&amp;t=0s\" target=\"_blank\" rel=\"noopener noreferrer\"><em><strong>Fibrodisplazija osifikuese progressive (FOP)<\/strong><\/em><\/a><\/p>\n<p>Fybrodysplasia ossificans progressiva (FOP)<\/p>\n<p>Fybrodysplasia ossificans progressiva (FOP) \u00ebsht\u00eb nj\u00eb nga s\u00ebmundjet m\u00eb t\u00eb ralla n\u00eb bot\u00eb, deri m\u00eb tani jan\u00eb t\u00eb dijagnostifikuar reth 800 pacient\u00eb me k\u00ebt\u00eb s\u00ebmundje n\u00eb nivel global.<br \/>\nPrevalenca e FOP \u00ebsht\u00eb 1 n\u00eb 2 000 000 banor.<br \/>\nKy termin i nd\u00ebrlikuar latin q\u00eb sh\u00ebnon emrin e s\u00ebmundjes n\u00eb t\u00eb v\u00ebrtet n\u00eb m\u00ebnyr\u00eb perfekte e p\u00ebrshkruan se p\u00ebr \u00e7far s\u00ebmundje b\u00ebhet fjal\u00eb. Tek njer\u00ebzit me FOP, indi lidhor dhe muskulor (tetivat dhe ligamentet) gradualisht sh\u00ebndrohen n\u00eb eshtra. Duke mar\u00eb parasysh simptomet e k\u00ebsaj s\u00ebmundje, sinonim p\u00ebr FOP \u00ebsht\u00eb s\u00ebmudnja e ashtuquajtur \u201cNjeriu gurr\u201d ( ang. Stoneman disease).<br \/>\nRasti I par\u00eb I FOP \u00ebsht\u00eb I regjistruar q\u00eb n\u00eb shekullin e 17, por ather\u00eb \u00ebsht\u00eb besuar q\u00eb osifikimi i indit muskulor paraqitet si rezultat I pro\u00e7esit inflamator q\u00eb zhvilohet n\u00eb indin muskulor. Ne vitin 1970, Victor A McKusick ka v\u00ebrjtur q\u00eb indi muskulor nuk \u00ebsht\u00eb i vetmi q\u00eb sh\u00ebndrohet n\u00eb eshtra, e njejta ndodh edhe me ligamentet. At\u00ebher s\u00ebmundja e mer emrin e vet, q\u00eb shfrytezohet edhe sot.<br \/>\nShkaku per paraqitjen e k\u00ebsaj s\u00ebmundje \u00ebsht\u00eb mutacioni i gjenit ACVR1 dhe gjithmon\u00eb paraqitet n\u00eb sekuencen e njejt\u00eb te gjenit, kurse s\u00ebmundja trash\u00ebgohet ne menyre autozome dominante, q\u00eb do t\u00eb thot\u00eb se nj\u00eb kopie e gjenit t\u00eb ndryshuar n\u00eb qeliz\u00eb \u00ebsht\u00eb e mjaftueshme q\u00eb ta shkakton k\u00ebt\u00eb s\u00ebmundje. Per k\u00ebt\u00eb shkak, f\u00ebmijet e prinderve, tek t\u00eb cilet njeri prind \u00ebsht\u00eb heterozigot dhe ka FOP, kurse tjetri prind ne asnje menyre nuk \u00ebsht\u00eb i lidhur me FOP, ekziston 50% mundesi qe tek femiu te paraqitet FOP.<br \/>\nSimptomi ky\u00e7 p\u00ebr dijagnoz\u00eb t\u00eb sakt\u00eb \u00ebsht\u00eb deformiteti q\u00eb paraqitet tek gishtat e njerzeve q\u00eb lidning me FOP, dhe I njejti dallohet q\u00eb n\u00eb lindje. FOP karakterizohet me osifikim progresiv te muskujve, ligamenteve, tetivave dhe indit te bute, q\u00eb rezulton me formimin e mases shtese skeletore duke shkaktuar d\u00ebme te perhershme dhe invaliditet te r\u00ebnde fizik. Shumica e njerezve ne FOP kan\u00eb nevoj t\u00eb p\u00ebrdorin karroce p\u00ebr invalide.<br \/>\nSimpotomet fillojn\u00eb q\u00eb n\u00eb f\u00ebmijerin\u00eb e hershme dhe manifestohen me edem ne kok\u00eb, qaf\u00eb apo shpin\u00eb, i cili me pas sh\u00ebnderohet ne asht. \u00c7do tentim q\u00eb ashti i posaformurar apo cila do forme e traumes fizike (biopsi, injekcion, nderhyrje kirurgjike, sulm ne tru) apo metabolike tek pacient\u00ebt me FOP bjen deri tek progresion i pandalsh\u00ebm dhe formim t\u00eb ri t\u00eb mases eshtrore dhe paraqitje te invaliditetit.<br \/>\n\u00cbsht\u00eb tejet e r\u00ebndesishme q\u00eb t\u00eb punohet ne drejtimin e ritjes te nd\u00ebrgjegj\u00ebsimit n\u00eb lidhje me FOP pasi q\u00eb intervenimet e gabuara si dhe dijagnostifikimi i gabuar jan\u00eb fatal p\u00ebr njerezit me FOP. Edhe pse n\u00eb princip FOP nuk i afekton organet e mbrendshme, zemra, dhe posaq\u00ebrisht mushk\u00ebrite jan\u00eb t\u00eb prekura nga fakti qe trupi sh\u00ebnderohet n\u00eb nj\u00eb mburoj\u00eb nga ashti.<br \/>\nFibrodisplazija progresive osifikuese e sulmon organizmin duke filluar nga muskujt dhe nyjet e kok\u00ebs, qaf\u00ebs, regjioniot dorzal, kraherorin, supet dhe eksremitetet e lartme, kurse me pas i afekton muskujt dhe funkcionimin e nyjeve ne regjionin e abdomenit, regjionit lumbal dhe ekstremitetet e poshtme.<br \/>\nSi rezultat i gjithe kesaj, FOP rezulton me humbjen e aft\u00ebsise p\u00ebr t\u00eb l\u00ebvizur me d\u00ebme the perhershme mbi shkatht\u00ebsite motorike te pacientit.<br \/>\nFOP i afekton absolutisht t\u00eb gjith\u00eb muskujt ne trupin e njeriut, duke i p\u00ebrfshire edhe muskujt q\u00eb mund\u00ebsojne levizjen e nofullave. Kjo \u00ebsht arsyeja q\u00eb shumica e pacienteve q\u00eb kan\u00eb k\u00ebt\u00eb s\u00ebmundje t\u00eb ralle nuk mundin ta levizin nofullen duke mos mundur as t\u00eb ushqehen. Per kete shkak, njerezit me FOP q\u00eb t\u00eb mbijetojn\u00eb e kan\u00eb t\u00eb domosdoshme te perdorin ushqim enteral, preparate t\u00eb l\u00ebngshme t\u00eb cilat i p\u00ebrmbajn\u00eb t\u00eb gjitha komponentat esencijale t\u00eb nevojshme p\u00ebr organizimin.<br \/>\nFOP nuk manifestohet n\u00eb disa pjes\u00eb t\u00eb trupit t\u00eb njeriut. P\u00ebr shembull, nuk shkakton formim e formacioneve eshtrore n\u00eb gjuh\u00eb, miokard, muskujt e lemuar, muskujt ekstraokular dhe dijafragm\u00eb\/<br \/>\nTerapi:<br \/>\nOpcionet p\u00ebr tretmat t\u00eb FOP jane simptomatike t\u00eb kah\u00ebzuara kundrejt zbutjes t\u00eb simptomatologjis\u00eb dhe prolongim t\u00eb komplikimeve pasi q\u00eb deri m\u00eb tani nuk eksizton ila\u00e7 p\u00ebr ta sh\u00ebruar k\u00ebt\u00eb s\u00ebmundje, i cili mundet ta ndaloj mutacionin dhe pasojat.<br \/>\nHarry Eastlack \u00ebsht\u00eb pacienti m\u00eb i njohur me FOP. Simptomet e tija jan\u00eb intenzivuar n\u00eb moshen 10 vje\u00e7are, kurse para vdekjes se tij nga pneumonija shum\u00eb shpejt para dit\u00eblindjes se kat\u00ebrdhjet\u00eb, indet e tij kane qen\u00eb te osifikuara deri n\u00eb at\u00eb shkall\u00eb q\u00eb ka pasur mundesi t\u00eb levize vetem buzet. I vet\u00ebdijsh\u00ebm p\u00ebr s\u00ebmundjen e tij t\u00eb rall\u00eb, ai ka donuar trupin e tij per shkaqe shkencore. Skeleti I tij sot \u00ebsht\u00eb I vendosur ne muzein \u201cM\u00fctter\u201d ne Filadelfija.<br \/>\nDita per nd\u00ebrgjegj\u00ebsim per FOP \u00ebsht\u00eb 23 prilli.<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Fibrodisplazija osifikuese progressive (FOP) Fybrodysplasia ossificans progressiva (FOP) Fybrodysplasia ossificans progressiva (FOP) \u00ebsht\u00eb nj\u00eb nga s\u00ebmundjet m\u00eb t\u00eb ralla n\u00eb [&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":107510,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_mo_disable_npp":"","inline_featured_image":false},"categories":[1794],"tags":[],"imageURL":"https:\/\/sdk.mk\/wp-content\/uploads\/2020\/02\/24-Fybrodysplasia-ossificans-progressiva-FOP-650x366.png","thumbURL":"https:\/\/sdk.mk\/wp-content\/uploads\/2020\/02\/24-Fybrodysplasia-ossificans-progressiva-FOP-250x141.png","categoryNames":["Uncategorized"],"feature_caption":"","subtitle":"","views":"2393","source":"\u0421\u043a\u043e\u043f\u0458\u0435, (\u0421\u0410\u041a\u0410\u041c\u0414\u0410\u041a\u0410\u0416\u0410\u041c.\u041c\u041a)","yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v15.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>JU NJOFTOJM\u00cb ME S\u00cbMUNDJET E RRALLA: FIBRODISPLAZIJA OSIFIKUESE PROGRESSIVE - \u0421\u0430\u043a\u0430\u043c \u0414\u0430 \u041a\u0430\u0436\u0430\u043c<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sdk.mk\/index.php\/uncategorized-sq\/ju-njoftojme-me-semundjet-e-rralla-fibrodisplazija-osifikuese-progressive\/\" \/>\n<meta property=\"og:locale\" content=\"mk_MK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"JU NJOFTOJM\u00cb ME S\u00cbMUNDJET E RRALLA: FIBRODISPLAZIJA OSIFIKUESE PROGRESSIVE - \u0421\u0430\u043a\u0430\u043c \u0414\u0430 \u041a\u0430\u0436\u0430\u043c\" \/>\n<meta property=\"og:description\" content=\"Fibrodisplazija osifikuese progressive (FOP) Fybrodysplasia ossificans progressiva (FOP) Fybrodysplasia ossificans progressiva (FOP) \u00ebsht\u00eb nj\u00eb nga s\u00ebmundjet m\u00eb t\u00eb ralla n\u00eb [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sdk.mk\/index.php\/uncategorized-sq\/ju-njoftojme-me-semundjet-e-rralla-fibrodisplazija-osifikuese-progressive\/\" \/>\n<meta property=\"og:site_name\" content=\"\u0421\u0430\u043a\u0430\u043c \u0414\u0430 \u041a\u0430\u0436\u0430\u043c\" \/>\n<meta property=\"article:published_time\" content=\"2020-02-24T08:01:09+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sdk.mk\/wp-content\/uploads\/2020\/02\/24-Fybrodysplasia-ossificans-progressiva-FOP.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n<meta property=\"fb:app_id\" content=\"2407985809428537\" \/>\n<meta name=\"twitter:card\" content=\"summary\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebSite\",\"@id\":\"https:\/\/sdk.mk\/#website\",\"url\":\"https:\/\/sdk.mk\/\",\"name\":\"\\u0421\\u0430\\u043a\\u0430\\u043c \\u0414\\u0430 \\u041a\\u0430\\u0436\\u0430\\u043c\",\"description\":\"\\u0417\\u0430 \\u0441\\u043b\\u043e\\u0431\\u043e\\u0434\\u043e\\u0443\\u043c\\u043d\\u0438\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":\"https:\/\/sdk.mk\/?s={search_term_string}\",\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"mk-MK\"},{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/sdk.mk\/index.php\/uncategorized-sq\/ju-njoftojme-me-semundjet-e-rralla-fibrodisplazija-osifikuese-progressive\/#primaryimage\",\"inLanguage\":\"mk-MK\",\"url\":\"https:\/\/sdk.mk\/wp-content\/uploads\/2020\/02\/24-Fybrodysplasia-ossificans-progressiva-FOP.png\",\"width\":1920,\"height\":1080},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sdk.mk\/index.php\/uncategorized-sq\/ju-njoftojme-me-semundjet-e-rralla-fibrodisplazija-osifikuese-progressive\/#webpage\",\"url\":\"https:\/\/sdk.mk\/index.php\/uncategorized-sq\/ju-njoftojme-me-semundjet-e-rralla-fibrodisplazija-osifikuese-progressive\/\",\"name\":\"JU NJOFTOJM\\u00cb ME S\\u00cbMUNDJET E RRALLA: FIBRODISPLAZIJA OSIFIKUESE PROGRESSIVE - \\u0421\\u0430\\u043a\\u0430\\u043c \\u0414\\u0430 \\u041a\\u0430\\u0436\\u0430\\u043c\",\"isPartOf\":{\"@id\":\"https:\/\/sdk.mk\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/sdk.mk\/index.php\/uncategorized-sq\/ju-njoftojme-me-semundjet-e-rralla-fibrodisplazija-osifikuese-progressive\/#primaryimage\"},\"datePublished\":\"2020-02-24T08:01:09+00:00\",\"dateModified\":\"2020-02-24T08:01:09+00:00\",\"author\":{\"@id\":\"https:\/\/sdk.mk\/#\/schema\/person\/864d4cb4c82a45f771023b00a4aa5176\"},\"inLanguage\":\"mk-MK\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/sdk.mk\/index.php\/uncategorized-sq\/ju-njoftojme-me-semundjet-e-rralla-fibrodisplazija-osifikuese-progressive\/\"]}]},{\"@type\":\"Person\",\"@id\":\"https:\/\/sdk.mk\/#\/schema\/person\/864d4cb4c82a45f771023b00a4aa5176\",\"name\":\"Biljana Nestoroska\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","_links":{"self":[{"href":"https:\/\/sdk.mk\/index.php\/wp-json\/wp\/v2\/posts\/107512"}],"collection":[{"href":"https:\/\/sdk.mk\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sdk.mk\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sdk.mk\/index.php\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/sdk.mk\/index.php\/wp-json\/wp\/v2\/comments?post=107512"}],"version-history":[{"count":0,"href":"https:\/\/sdk.mk\/index.php\/wp-json\/wp\/v2\/posts\/107512\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sdk.mk\/index.php\/wp-json\/wp\/v2\/media\/107510"}],"wp:attachment":[{"href":"https:\/\/sdk.mk\/index.php\/wp-json\/wp\/v2\/media?parent=107512"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sdk.mk\/index.php\/wp-json\/wp\/v2\/categories?post=107512"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sdk.mk\/index.php\/wp-json\/wp\/v2\/tags?post=107512"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}