{"id":165756,"date":"2022-02-11T09:02:39","date_gmt":"2022-02-11T08:02:39","guid":{"rendered":"https:\/\/sdk.mk\/?p=165756"},"modified":"2022-02-11T09:02:39","modified_gmt":"2022-02-11T08:02:39","slug":"ju-njoftojme-me-semundjet-e-rralla-sindroma-goodpasture","status":"publish","type":"post","link":"https:\/\/sdk.mk\/index.php\/maqedonia\/ju-njoftojme-me-semundjet-e-rralla-sindroma-goodpasture\/","title":{"rendered":"JU NJOFTOJM\u00cb ME S\u00cbMUNDJET E RRALLA: SINDROMA GOODPASTURE"},"content":{"rendered":"<div class=\"f52428582a4b906b2d2e2a7d733c7d27\" data-index=\"7\" style=\"float: none; margin:10px 0 10px 0; text-align:center;\">\n<!-- MSP Ads Asynchronous JS Tag - Generated with Revive Adserver v5.4.1 -->\r\n<ins data-revive-zoneid=\"167\" data-revive-id=\"060fdb01f6430ec164d3519234aa4967\"><\/ins>\r\n<script async src=\"\/\/panel.ads.com.mk\/www\/delivery\/asyncjs.php\"><\/script>\n<\/div>\n<p><em><strong>Sindroma Goodpasture\/Goodpasture syndrome<\/strong><\/em><\/p>\n<p>ICD: \u041c 31.0 + N 08.5<\/p>\n<p>Prevalenca: 1-9\/1.000.000<\/p>\n<p>Sindroma Goodpasture paraqet nj\u00eb grup s\u00ebmundjesh akute q\u00eb kapin mushk\u00ebrit\u00eb dhe veshkat, gjeneza e t\u00eb cil\u00ebs \u00ebsht\u00eb nj\u00eb \u00e7rregullim autoimun. Normalisht, sistemi imunitar prodhon antitrupa p\u00ebr t\u2019u mbrojtur nga mikrobet e jashtme. Por, n\u00eb k\u00ebt\u00eb sindrom\u00eb, sistemi imunitar prodhon antitrupa q\u00eb sulmojn\u00eb en\u00ebt e vogla t\u00eb gjakut, kapilar\u00ebt e vendosur n\u00eb mushk\u00ebri dhe veshka, duke shkaktuar glomerulonefrit dhe insuficienc\u00eb t\u00eb veshkave, si dhe gjakderdhje n\u00eb mushk\u00ebri.<\/p>\n<p>Shfaqet tek aziatik\u00ebt dhe europian\u00ebt e rac\u00ebs s\u00eb bardh\u00eb, pothuajse nj\u00ebsoj n\u00eb t\u00eb dy gjinit\u00eb. Kjo s\u00ebmundje \u00ebsht\u00eb p\u00ebrgjegj\u00ebse p\u00ebr 1-5% t\u00eb t\u00eb gjitha rasteve t\u00eb glomerulonefritit dhe shkaku i rreth 10-15% t\u00eb glomerulonefriteve me ecuri t\u00eb shpejt\u00eb. Zakonisht shfaqet n\u00eb dekad\u00ebn e dyt\u00eb ose t\u00eb shtat\u00eb t\u00eb jet\u00ebs.<br \/>\nSimptomat q\u00eb shfaqen n\u00eb mushk\u00ebri p\u00ebrfshijn\u00eb episode t\u00eb p\u00ebrs\u00ebritura t\u00eb kollitjes duke nxjerr\u00eb g\u00eblbaz\u00eb me gjak, gul\u00e7im, lodhje, dhimbje gjoksi dhe simptomat nga veshka p\u00ebrfshijn\u00eb gjak n\u00eb urin\u00eb, djegie, v\u00ebshtir\u00ebsi n\u00eb urinim dhe dhimbje n\u00eb pjes\u00ebn e poshtme t\u00eb shpin\u00ebs.<\/p>\n<p>N\u00eb vitin 1919 gjat\u00eb epidemis\u00eb s\u00eb gripit, patologu amerikan Ernest William Goodpasture e p\u00ebrshkroi p\u00ebr her\u00eb t\u00eb par\u00eb k\u00ebt\u00eb sindrom\u00eb, pas s\u00eb cilit u em\u00ebrua.<\/p>\n<p><strong>Shkaqet:<\/strong><\/p>\n<p>Sindroma Goodpasture zhvillohet p\u00ebr arsye t\u00eb panjohura. Kur ndodh nj\u00eb infeksion, antitrupat, si mbrojtje natyrore e trupit, luftojn\u00eb trupin e huaj (p.sh. viruset ose bakteret). Te s\u00ebmundjet autoimune, antitrupat sulmojn\u00eb indet e sh\u00ebndetshme pa ndonj\u00eb arsye t\u00eb dukshme. Faktor\u00ebt e mjedisit, t\u00eb tilla si ekspozimi ndaj hidrokarbureve, cigareve ose infeksioneve t\u00eb tilla si gripi, mund t\u00eb luajn\u00eb nj\u00eb rol n\u00eb zhvillimin e k\u00ebsaj s\u00ebmundjeje. Hemorragjia pulmonare \u00ebsht\u00eb e zakonshme te pacient\u00ebt me sindrom\u00ebn Goodpasture t\u00eb cil\u00ebt jan\u00eb regjistruar si duhanpir\u00ebs.<\/p>\n<p>Te sindroma Goodpasture antitrupa t\u00eb caktuar, si\u00e7 jan\u00eb antitrupat ndaj membran\u00ebs bazale glomerulare (anti-GBM) mund t\u00eb prodhohen dhe t\u00eb qarkullojn\u00eb n\u00eb gjak. K\u00ebto antitrupa d\u00ebmtojn\u00eb membran\u00ebn delikate dhe komplekse t\u00eb vendosur n\u00eb mushk\u00ebri dhe veshka, dhe k\u00ebshtu i d\u00ebmtojn\u00eb en\u00ebt e vogla t\u00eb gjakut n\u00eb to. N\u00eb disa raste, Sindroma Goodpasture \u00ebsht\u00eb raportuar n\u00eb m\u00eb shum\u00eb se nj\u00eb an\u00ebtar t\u00eb familjes, duke konfirmuar mund\u00ebsin\u00eb e predispozicionit gjenetik. Ai q\u00eb ka nj\u00eb predispozit\u00eb gjenetike ndaj k\u00ebsaj s\u00ebmundje mbart nj\u00eb gjen t\u00eb till\u00eb specifik, por s\u00ebmundja nuk do t\u00eb shfaqet derisa t\u00eb nxitet apo aktivizohet n\u00eb rrethana t\u00eb caktuara, nga disa faktor\u00eb t\u00eb mjedisit.<\/p>\n<p><strong>Simptomat:<\/strong><\/p>\n<p>Simptomat kryesor\u00eb t\u00eb sindrom\u00ebs Goodpasture jan\u00eb gjakderdhja e r\u00ebnd\u00eb n\u00eb mushk\u00ebri dhe inflamacioni i glomeruleve, ose glomerulonefriti. N\u00eb disa raste, infeksioni i traktit respirator i paraprin zhvillimit t\u00eb k\u00ebsaj sindrome. Hemorragjia pulmonare manifestohet ashtu q\u00eb pacienti p\u00ebshtyn gjak kur kollitet &#8211; hemoptiz\u00eb. Ka edhe dispne, lodhje, dhimbje gjoksi, kollitje t\u00eb shpesht\u00eb, etj. Ndryshimet pulmonare zakonisht shihen m\u00eb her\u00ebt ose n\u00eb t\u00eb nj\u00ebjt\u00ebn koh\u00eb me ndryshimet veskore n\u00eb rreth 70% t\u00eb rasteve. Ashp\u00ebrsia e simptomave respirator\u00eb ndryshon nga ekspektorimi i disa pikave t\u00eb gjakut, n\u00eb gjakderdhje t\u00eb bollshme, dhe duke arritur kulmin me akumulimin e l\u00ebngjeve n\u00eb indet e mushk\u00ebrive \u2013 edema pulmonare.<\/p>\n<p>Nga ana tjet\u00ebr, kur b\u00ebhet fjal\u00eb p\u00ebr veshkat, pacient\u00ebt zhvillojn\u00eb inflamacion t\u00eb strukturave t\u00eb filtrit, glomerul\u00ebve, dhe ky inflamacion paraqet glomerulonefrit. Si rezultat, veshkat kan\u00eb nj\u00eb aft\u00ebsi t\u00eb reduktuar p\u00ebr t\u00eb filtruar dhe p\u00ebr t\u00eb m\u00ebnjanuar materiet toksike nga gjaku n\u00eb urin\u00eb, t\u00eb gjitha k\u00ebto shoq\u00ebrohen me insuficienc\u00eb akute renale. Insuficienca renale \u00e7on n\u00eb uljen e prodhimit t\u00eb urin\u00ebs. Simptoma shtes\u00eb, t\u00eb shoq\u00ebruara me insuficienc\u00ebn renale, p\u00ebrfshijn\u00eb l\u00ebkur\u00eb t\u00eb zbeht\u00eb, gjendje t\u00eb keqe, t\u00eb p\u00ebrziera dhe t\u00eb vjella.<\/p>\n<p>Komplikimet e r\u00ebnda p\u00ebrfshijn\u00eb gjakderdhje n\u00eb bark dhe ulje t\u00eb qelizave t\u00eb kuqe t\u00eb gjakut dmth. Anemi. N\u00eb raste t\u00eb rralla, pacient\u00ebt mund t\u00eb p\u00ebrjetojn\u00eb presion t\u00eb lart\u00eb t\u00eb gjakut, si dhe \u00ebnjtje t\u00eb ky\u00e7eve. Simptomat e p\u00ebrgjithshme te pacient\u00ebt me sindrom\u00ebn Goodpasture jan\u00eb lodhja, ethet e lehta, l\u00ebkura e zbeht\u00eb dhe humbja e pesh\u00ebs.<\/p>\n<p><strong>Pasojat:<\/strong><\/p>\n<p>Te nj\u00eb num\u00ebr i madh pacient\u00ebsh, 80-90%, kjo s\u00ebmundje do t\u00eb rezultoj\u00eb me simptoma t\u00eb glomerulonefritit me ecuri t\u00eb shpejt\u00eb, 40-60% e pacient\u00ebve do t\u00eb ken\u00eb gjithashtu hemorragji pulmonare, nd\u00ebrsa te nj\u00eb num\u00ebr i vog\u00ebl pacient\u00ebsh do t\u00eb shfaqet s\u00ebmundje e izoluar e mushk\u00ebrive.<\/p>\n<p>Megjith\u00ebse Sindroma Goodpasture mund t\u00eb shkaktoj\u00eb gjakderdhje t\u00eb rrezikshme p\u00ebr jet\u00ebn n\u00eb mushk\u00ebri, ajo zakonisht nuk rezulton n\u00eb d\u00ebmtime afatgjata t\u00eb mushk\u00ebrive. Pas trajtimit spitalor, k\u00ebrkohen kontrolle t\u00eb rregullta dhe t\u00eb shpeshta te k\u00ebta pacient\u00eb p\u00ebr t\u00eb monitoruar funksionin e veshkave dhe p\u00ebr t\u00eb vler\u00ebsuar terapin\u00eb imunosupresive. Pasoja m\u00eb serioze e sindrom\u00ebs Goodpasture \u00ebsht\u00eb insuficienca renale e cila mund t\u00eb k\u00ebrkoj\u00eb dializ\u00eb ose transplantim t\u00eb veshkave te k\u00ebta pacient\u00eb.<\/p>\n<p><strong>Trajtimi:<\/strong><\/p>\n<p>Sindroma Goodpasture trajtohet n\u00eb m\u00ebnyr\u00eb t\u00eb shpejt\u00eb dhe agresive p\u00ebr t\u00eb hequr antitrupat e d\u00ebmsh\u00ebm, nj\u00ebkoh\u00ebsisht duke kontrolluar marrjen e l\u00ebngjeve, duke monitoruar presionin e gjakut dhe duke parandaluar d\u00ebmtimet serioze t\u00eb veshkave dhe mushk\u00ebrive.<\/p>\n<p>Format e lehta t\u00eb sindrom\u00ebs Goodpasture mund t\u00eb trajtohen me imunosupresant\u00eb, m\u00eb s\u00eb shpeshti oral. Kjo terapi synon t\u00eb zvog\u00ebloj\u00eb prodhimin e antitrupave anti GBM nga sistemi imunitar. Kortikosteroidet mund t\u00eb ky\u00e7en n\u00eb terapi p\u00ebr t\u00eb kontrolluar gjakderdhjen n\u00eb mushk\u00ebri. N\u00eb var\u00ebsi t\u00eb p\u00ebrgjigjes s\u00eb trupit ndaj terapis\u00eb, trajtimi me imunosupresant\u00eb mund t\u00eb zgjatet nga 6 gjer n\u00eb 12 muaj. Shum\u00eb pacient\u00eb gjithashtu do t\u00eb ken\u00eb nevoj\u00eb p\u00ebr plazmaferez\u00eb. Kjo procedur\u00eb \u00ebsht\u00eb nj\u00eb metod\u00eb q\u00eb largon substancat e pad\u00ebshiruara (toksinat, antitrupat dhe metabolit\u00ebt) nga gjaku. Plazmafereza shpesh aplikohet s\u00eb bashku me kortikosteroidet. N\u00eb raste t\u00eb r\u00ebnda dhe t\u00eb p\u00ebrs\u00ebritura t\u00eb sindrom\u00ebs Goodpasture, pacient\u00ebt gjithashtu mund t\u00eb trajtohen me dializ\u00eb p\u00ebr t\u00eb hequr toksinat nga gjaku. N\u00eb rastet m\u00eb t\u00eb r\u00ebnda kur dializa \u00ebsht\u00eb e pasuksesshme, at\u00ebher\u00eb nevojitet nj\u00eb transplant i veshkave. N\u00ebse nuk trajtohet n\u00eb koh\u00eb, prognoza e k\u00ebsaj s\u00ebmundjeje \u00ebsht\u00eb e keqe. Ajo kryesisht varet nga d\u00ebmtimi i veshkave.<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sindroma Goodpasture\/Goodpasture syndrome ICD: \u041c 31.0 + N 08.5 Prevalenca: 1-9\/1.000.000 Sindroma Goodpasture paraqet nj\u00eb grup s\u00ebmundjesh akute q\u00eb kapin [&hellip;]<\/p>\n","protected":false},"author":22,"featured_media":165759,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_mo_disable_npp":"no","inline_featured_image":false},"categories":[3087],"tags":[56990],"imageURL":"https:\/\/sdk.mk\/wp-content\/uploads\/2022\/02\/11-Goodpasture-syndrome-1-650x366.png","thumbURL":"https:\/\/sdk.mk\/wp-content\/uploads\/2022\/02\/11-Goodpasture-syndrome-1-250x141.png","categoryNames":["Maqedonia"],"feature_caption":"","subtitle":"","views":"332","source":"\u0421\u043a\u043e\u043f\u0458\u0435, (\u0421\u0410\u041a\u0410\u041c\u0414\u0410\u041a\u0410\u0416\u0410\u041c.\u041c\u041a)","yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v15.0 - 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