{"id":188613,"date":"2023-02-13T08:22:55","date_gmt":"2023-02-13T07:22:55","guid":{"rendered":"https:\/\/sdk.mk\/?p=188613"},"modified":"2023-02-13T08:22:55","modified_gmt":"2023-02-13T07:22:55","slug":"ju-njoftojme-me-semundjet-e-rralla-ethet-familjare-mesdhetare","status":"publish","type":"post","link":"https:\/\/sdk.mk\/index.php\/maqedonia\/ju-njoftojme-me-semundjet-e-rralla-ethet-familjare-mesdhetare\/","title":{"rendered":"JU NJOFTOJM\u00cb ME S\u00cbMUNDJET E RRALLA: ETHET FAMILJARE MESDHETARE"},"content":{"rendered":"<div class=\"f52428582a4b906b2d2e2a7d733c7d27\" data-index=\"7\" style=\"float: none; margin:10px 0 10px 0; text-align:center;\">\n<!-- MSP Ads Asynchronous JS Tag - Generated with Revive Adserver v5.4.1 -->\r\n<ins data-revive-zoneid=\"167\" data-revive-id=\"060fdb01f6430ec164d3519234aa4967\"><\/ins>\r\n<script async src=\"\/\/panel.ads.com.mk\/www\/delivery\/asyncjs.php\"><\/script>\n<\/div>\n<p><em><strong>Ethet familjare mesdhetare\/Familial Mediterranean fever (FMF)<\/strong><\/em><\/p>\n<p>\u041c\u041a\u0411 10: E 85.0<\/p>\n<p>Prevalenca (prevalenca): 1-5\/10.000<\/p>\n<p>Ethet Familjare Mesdhetare (FMF) \u00ebsht\u00eb nj\u00eb \u00e7\u2019rregullim gjenetik autoinflamator q\u00eb shkakton ethe t\u00eb p\u00ebrs\u00ebritura dhe inflamacion t\u00eb dhimbshme t\u00eb barkut, mushk\u00ebrive dhe ky\u00e7eve. FMF \u00ebsht\u00eb nj\u00eb s\u00ebmundje e trash\u00ebguar q\u00eb m\u00eb s\u00eb shpeshti prek njer\u00ebzit me prejardhje mesdhetare -duke p\u00ebrfshir\u00eb ata me origjin\u00eb afrikano-veriore, hebreje, arabe, armene, turke, greke ose italiane. Por mund t\u00eb prek\u00eb njer\u00ebzit e \u00e7do grupi etnik.<\/p>\n<p><strong>Simptomat:<\/strong><\/p>\n<p>Ethet familjare mesdhetare kryesisht shkaktojn\u00eb inflamacion t\u00eb l\u00ebkur\u00ebs, organeve t\u00eb brendshme dhe ky\u00e7eve. Sulmet e s\u00ebmundjes karakterizohen nga sulme nj\u00eb-ditore ose tre-ditore t\u00eb dhimbjes s\u00eb kok\u00ebs dhe ethe me gjendje t\u00eb tjera inflamatore, t\u00eb tilla si:<\/p>\n<p>-pleurit, inflamacion i mukoz\u00ebs s\u00eb mushk\u00ebrive, i karakterizuar nga frym\u00ebmarrje t\u00eb dhimbshme;<br \/>\n&#8211;peritonit, pezmatim i murit abdominal, i karakterizuar me dhimbje, ndjeshm\u00ebri, ethe, nauze dhe t\u00eb vjella;<br \/>\n-perikardit, inflamacion i mukoz\u00ebs s\u00eb zemr\u00ebs, i karakterizuar nga dhimbje t\u00eb mprehta, ther\u00ebse n\u00eb gjoks;<br \/>\n-meningjiti, inflamacion i membranave q\u00eb mbulojn\u00eb trurin dhe palc\u00ebn kurrizore;<br \/>\n-artralgji (dhimbje ky\u00e7esh) dhe artrit (inflamacion i ky\u00e7eve);-skuqje inflamatore e p\u00ebrhapur, zakonisht posht\u00eb gjurit;-mialgji (dhimbje muskulore) e cila mund t\u00eb jet\u00eb e r\u00ebnd\u00eb;<br \/>\n-inflamacion i testikujve q\u00eb shkakton dhimbje dhe \u00ebnjtje (q\u00eb mund t\u00eb rris\u00eb rrezikun e infertilitetit);<br \/>\n-zgjerimi i shpretk\u00ebs.<\/p>\n<p>Ashp\u00ebrsia e simptomave varion nga t\u00eb lehta n\u00eb m\u00eb t\u00eb r\u00ebnda . Frekuenca e sulmeve mund t\u00eb ndryshoj\u00eb me kalimin e dit\u00ebve ose viteve.Edhe pse shenjat e etheve mesdhetare familjare mund t\u00eb zhvillohen q\u00eb n\u00eb f\u00ebmij\u00ebri, ato m\u00eb shpesh fillojn\u00eb n\u00eb t\u00eb 20-at.<\/p>\n<p><strong>Shkaqet:<\/strong><\/p>\n<p>Ethet familjare mesdhetare shkaktohen nga nj\u00eb mutacion n\u00eb gjenin MEVF n\u00eb krahun e shkurt\u00ebr t\u00eb kromozomit 16.Mutacioni i gjenit shkakton probleme n\u00eb rregullimin e inflamacionit n\u00eb trup.S\u00ebmundja trash\u00ebgohet n\u00eb m\u00ebnyr\u00eb autozomale recesive.<\/p>\n<p><strong>Komplikimet:<\/strong><\/p>\n<p>N\u00ebse ethet familjare mesdhetare nuk trajtohen, mund t\u00eb ndodhin komplikime duke p\u00ebrfshir\u00eb nivele jonormale t\u00eb proteinave n\u00eb gjak. Gjat\u00eb nj\u00eb sulmi t\u00eb etheve mesdhetare familjare, trupi mund t\u00eb prodhoj\u00eb nj\u00eb sasi jonormale t\u00eb proteinave (amiloide A), t\u00eb grumbullohet n\u00eb trup dhe t\u00eb shkaktoj\u00eb d\u00ebmtim t\u00eb organeve (amilodoz\u00eb). Amiloidoza mund t\u00eb d\u00ebmtoj\u00eb veshkat, duke shkaktuar sindrom\u00ebn nefrotike, e cila ndodh kur d\u00ebmtohen sistemet e filtrimit t\u00eb veshkave (glomeruli). Njer\u00ebzit me k\u00ebt\u00eb gjendje mund t\u00eb humbasin sasi t\u00eb m\u00ebdha t\u00eb proteinave n\u00eb urin\u00eb. Sindroma nefrotike mund t\u00eb \u00e7oj\u00eb n\u00eb formimin e mpiksjes s\u00eb veshkave (tromboz\u00eb e venave renale) ose d\u00ebshtim t\u00eb veshkave. Inflamacioni i shkaktuar nga ethet familjare mesdhetare mund t\u00eb prek\u00eb edhe organet riprodhuese t\u00eb femr\u00ebs, duke shkaktuar infertilitet. Artriti \u00ebsht\u00eb i zakonsh\u00ebm tek njer\u00ebzit me ethe familjare mesdhetare. Nyjet m\u00eb t\u00eb prekura jan\u00eb gjunj\u00ebt,ky\u00e7et, ijet dhe b\u00ebrrylat.<\/p>\n<p><strong>Dijagnoza:<\/strong><\/p>\n<p>Diagnoza e etheve mesdhetare familjare bazohet kryesisht n\u00eb historin\u00eb dhe modelin e sulmeve. \u00c7el\u00ebsi p\u00ebr identifikimin e s\u00ebmundjes \u00ebsht\u00eb koh\u00ebzgjatja e sulmeve, e cila mund t\u00eb jet\u00eb m\u00eb e gjat\u00eb se tre dit\u00eb, por n\u00eb raste t\u00eb rralla. Testet laboratorike p\u00ebrfshijn\u00eb: analiz\u00eb e plot\u00eb t\u00eb gjakut, shkall\u00ebn e sedimentimit t\u00eb eritrociteve, protein\u00ebn C-reaktive, haptoglobin\u00ebn e serumit.Me an\u00eb t\u00eb analiz\u00ebs s\u00eb urin\u00ebs, vler\u00ebsohet n\u00ebse ka nj\u00eb tepric\u00eb t\u00eb albumin\u00ebs n\u00eb urin\u00eb, gj\u00eb q\u00eb tregon d\u00ebmtim kronik t\u00eb veshkave. Testimi gjenetik mund t\u00eb p\u00ebrcaktoj\u00eb n\u00ebse gjeni MEFV p\u00ebrmban nj\u00eb mutacion t\u00eb lidhur me ethet familjare mesdhetare.<\/p>\n<p><strong>Mjekimi:<\/strong><\/p>\n<p>Nuk ka kur\u00eb p\u00ebr ethet familjare mesdhetare. Megjithat\u00eb, trajtimi mund t\u00eb ndihmoj\u00eb n\u00eb parandalimin e disa shenjave dhe simptomave. Medikamentet q\u00eb p\u00ebrdoren p\u00ebr t\u00eb kontrolluar shenjat dhe simptomat e etheve familjare mesdhetare p\u00ebrfshijn\u00eb: kolkicin\u00ebn, e cila merret n\u00eb form\u00eb tabletash, redukton inflamacionin n\u00eb trup dhe ndihmon n\u00eb parandalimin e krizave. Konsultimi me nj\u00eb mjek \u00ebsht\u00eb i nevojsh\u00ebm p\u00ebr t\u00eb p\u00ebrcaktuar strategjin\u00eb m\u00eb t\u00eb mir\u00eb t\u00eb dozimit. Disa marrin nj\u00eb doz\u00eb n\u00eb dit\u00eb, nd\u00ebrsa t\u00eb tjer\u00eb kan\u00eb nevoj\u00eb p\u00ebr doza m\u00eb t\u00eb vogla dhe m\u00eb t\u00eb shpeshta. Efektet an\u00ebsore t\u00eb zakonshme p\u00ebrfshijn\u00eb fryrje, dhimbje barku dhe diarre. P\u00ebr njer\u00ebzit, shenjat dhe simptomat e t\u00eb cil\u00ebve nuk kontrollohen nga kolchicina, mund t\u00eb p\u00ebrshkruhen medikamente q\u00eb bllokojn\u00eb nj\u00eb protein\u00eb t\u00eb quajtur interleukin-1, e cila \u00ebsht\u00eb e p\u00ebrfshir\u00eb n\u00eb inflamacion. K\u00ebto barna p\u00ebrfshijn\u00eb kanakinumab (Ilaris), rilonacept (Arkalist) dhe anakinra (Kineret).<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Ethet familjare mesdhetare\/Familial Mediterranean fever (FMF) \u041c\u041a\u0411 10: E 85.0 Prevalenca (prevalenca): 1-5\/10.000 Ethet Familjare Mesdhetare (FMF) \u00ebsht\u00eb nj\u00eb \u00e7\u2019rregullim [&hellip;]<\/p>\n","protected":false},"author":22,"featured_media":188614,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_mo_disable_npp":"no","inline_featured_image":false},"categories":[3087],"tags":[],"imageURL":"https:\/\/sdk.mk\/wp-content\/uploads\/2023\/02\/13-Familial-Mediterranean-fever-1-650x366.png","thumbURL":"https:\/\/sdk.mk\/wp-content\/uploads\/2023\/02\/13-Familial-Mediterranean-fever-1-250x141.png","categoryNames":["Maqedonia"],"feature_caption":"","subtitle":"","views":"583","source":"\u0421\u043a\u043e\u043f\u0458\u0435, (\u0421\u0410\u041a\u0410\u041c\u0414\u0410\u041a\u0410\u0416\u0410\u041c.\u041c\u041a)","yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v15.0 - 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